2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-110233S
    Acamprosate-d6 calcium 1225580-91-5 98%
    Acamprosate-d6 (calcium) is the deuterium labeled Acamprosate calcium. Acamprosate calcium (Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems.
    Acamprosate-d6 calcium
  • HY-126061S
    1,7-Dimethyluric acid-d3 1189713-08-3 98%
    1,7-Dimethyluric acid-d3 is the deuterium labeled 1,7-Dimethyluric acid. 1,7-Dimethyluric acid is the metabolite of caffeine.
    1,7-Dimethyluric acid-d3
  • HY-128733S
    Phenyl acetate-d5 22705-26-6 98%
    Phenyl acetate-d5 is the deuterium labeled Phenyl acetate. Phenyl acetate is an endogenous metabolite and a metabolite of 2-phenylethylamine, which can be found in urine. Phenyl acetate regulates the metabolism of glutamine. In addition, Phenyl acetate can be used as a detection index for certain diseases, such as depression.
    Phenyl acetate-d5
  • HY-136610S
    Chlorpyrifos-oxon-d10 1794779-85-3 98%
    Chlorpyrifos-oxon-d10 is the deuterium labeled Chlorpyrifos-oxon. Chlorpyrifos-oxon, an active metabolite of Chlorpyrifos, is a potent phosphorylating agent that potently inhibits AChE. Chlorpyrifos-oxon can induce cross-linking between subunits of tubulin and disrupt microtubule function.
    Chlorpyrifos-oxon-d10
  • HY-138112S
    β-Dihydroequilin-d3 350820-03-0 98%
    β-Dihydroequilin-d3 is the deuterium labeled β-Dihydroequilin.
    β-Dihydroequilin-d3
  • HY-139509S
    Capsiamide-d3 1795031-33-2 98%
    Capsiamide-d3 is the deuterium labeled Capsiamide.
    Capsiamide-d3
  • HY-14545S1
    Amisulpride-d5 N-Oxide 1794756-15-2 98%
    Amisulpride-d5 N-Oxide is the deuterium labeled Amisulpride. Amisulpride is a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively.
    Amisulpride-d5 N-Oxide
  • HY-14546S1
    Aripiprazole (1,1,2,2,3,3,4,4-d8) 1089115-04-7 98%
    Aripiprazole (1,1,2,2,3,3,4,4-d8) is the deuterium labeled Aripiprazole. Aripiprazole (OPC-14597) is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM.
    Aripiprazole (1,1,2,2,3,3,4,4-d8)
  • HY-17034BS
    Medetomidine-d3 hydrochloride 1246820-20-1 98%
    Medetomidine-d3 (hydrochloride) is the deuterium labeled Medetomidine hydrochloride. Medetomidine hydrochloride is an agonist of adrenergic alpha-2 receptor.
    Medetomidine-d3 hydrochloride
  • HY-17038S1
    Agomelatine-d4 1079389-44-8 98%
    Agomelatine-d4 is the deuterium labeled Agomelatine. Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatine is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively.
    Agomelatine-d4
  • HY-B0176AS
    rel-Sertraline-d3 hydrochloride 1330180-66-9 98%
    rel-Sertraline-d3 (hydrochloride) is the deuterium labeled Sertraline hydrochloride. Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline hydrochloride is researched for a number of diseases, such as major depressive disorder and obsessive.
    rel-Sertraline-d3 hydrochloride
  • HY-B0189S1
    Mosapride-d5 1246820-66-5 98%
    Mosapride-d5 is the deuterium labeled Mosapride. Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist.
    Mosapride-d5
  • HY-B0246S1
    Carbamazepine-d2 1189902-21-3 98%
    Carbamazepine-d2 is the deuterium labeled Carbamazepine. Carbamazepine, a sodium channel blocker, is an anticonvulsant agent.
    Carbamazepine-d2
  • HY-B0274AS
    Chlorprothixene-d6 hydrochloride 98%
    Chlorprothixene-d6 hydrochloride is the deuterium labeled Chlorprothixene hydrochloride. Chlorprothixene hydrochloride is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity.
    Chlorprothixene-d6 hydrochloride
  • HY-B0457S1
    Clomipramine-d6 hydrochloride 1189882-28-7 98%
    Clomipramine-d6 (hydrochloride) is the deuterium labeled Clomipramine hydrochloride. Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine hydrochloride is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD).
    Clomipramine-d6 hydrochloride
  • HY-B0524AS
    Betahistine-d3 dihydrochloride 244094-72-2 ≥99.0%
    Betahistine-d3 (dihydrochloride) is the deuterium labeled Betahistine dihydrochloride. Betahistine dihydrochloride is an orally active histamine H1 receptor agonist and a H3 receptor antagonist. Betahistine dihydrochloride is used for the study of rheumatoid arthritis (RA).
    Betahistine-d3 dihydrochloride
  • HY-N0168AS
    (Rac)-Hesperetin-d3 1346605-26-2 98%
    (Rac)-Hesperetin-d3 is the deuterium labeled (Rac)-Hesperetin. (Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation.
    (Rac)-Hesperetin-d3
  • HY-108506S1
    Licarbazepine-d4 1020719-39-4 98%
    Licarbazepine-d4 is the deuterium labeled Licarbazepine (HY-108506). Licarbazepine is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects.
    Licarbazepine-d4
  • HY-W013425S
    2-Hydroxy-5-(phenyldiazenyl)benzoic acid-d5 1331662-16-8 98%
    2-Hydroxy-5-(phenyldiazenyl)benzoic acid-d5 is the deuterium labeled 2-Hydroxy-5-(phenyldiazenyl)benzoic acid.
    2-Hydroxy-5-(phenyldiazenyl)benzoic acid-d5
  • HY-W012722BS
    4-Methyl-2-oxopentanoic acid-d7 sodium 1795020-84-6 98%
    4-Methyl-2-oxopentanoic acid-d7 (α-Ketoisocaproic acid-d7) sodium is the deuterium labeled 4-Methyl-2-oxopentanoic acid (HY-W012722).4-Methyl-2-oxopentanoic acid is a metabolite of L-leucine and is involved in energy metabolism. 4-Methyl-2-oxopentanoic acid increases endoplasmic reticulum stress, promotes lipid accumulation in preadipocytes and insulin resistance by impairing mTOR and autophagy signaling pathways.
    4-Methyl-2-oxopentanoic acid-d7 sodium
Cat. No. Product Name / Synonyms Application Reactivity